Potensi Hidrolisat Protein Susu Kambing sebagai Sumber Peptida Bioaktif dengan Efek Antihipertensi

Ajriani Dainita Pajrin; Galang Prasaja Pambudi; Mugi Tyas Mandira; Nawang Wulan; Tanti Pebrianti; Distya Riski Hapsari

doi:10.30997/karimahtauhid.v4i1.16342

Authors

Ajriani Dainita Pajrin Universitas Djuanda
Galang Prasaja Pambudi Universitas Djuanda
Mugi Tyas Mandira Universitas Djuanda
Nawang Wulan Universitas Djuanda
Tanti Pebrianti Universitas Djuanda
Distya Riski Hapsari Universitas Djuanda

DOI:

https://doi.org/10.30997/karimahtauhid.v4i1.16342

Keywords:

Hidrolisat protein, kasein ẞ, antihipertensi, peptida bioaktif, susu kambing

Abstract

Penelitian ini bertujuan mengeksplorasi potensi hidrolisat protein susu kambing, terutama fraksi kasein ẞ, sebagai sumber peptida bioaktif dengan sifat antihipertensi. Proses hidrolisis dilakukan menggunakan enzim protease bromelin untuk menghasilkan peptida bermassa molekul rendah dengan bioavailabilitas tinggi. Derajat hidrolisis diukur untuk mengevaluasi efektivitas proses. Analisis in silico dan molecular docking digunakan untuk mengidentifikasi peptida bioaktif dengan daya inhibisi ACE (angiotensin-converting enzyme) yang lebih kuat dibandingkan lisinopril, inhibitor ACE komersial. Hasil menunjukkan bahwa hidrolisat protein susu kambing memiliki potensi sebagai solusi alami dan aman untuk pencegahan serta pengobatan hipertensi. Penelitian ini juga memberikan kontribusi pada pengembangan pangan fungsional berbasis susu kambing dengan menekankan pentingnya kontrol kualitas dalam penggunaannya.

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